White paper: The chilled future of RNA therapeutics — Filling & freezing applications

Aseptic filling & freezing of single-use bags are often performed manually and uncontrolled, leading to inefficiencies and increased product loss. Only modular technologies facilitate flexible manufacturing processes of mRNA, pDNA and viral vectors.
Different product characteristics come with different challenges and risks for fluid management. Sterile aliquotation into single-use bags and freezing for cryopreservation are often performed manually and uncontrolled. And therefore prone to inefficiencies and increased product loss. Modular and flexible technologies are the solution, as they facilitate the manufacturing process of mRNA, pDNA and viral vectors and optimize product quality. The adjustability of process solutions to different requirements and scenarios while adhering to cGMP will satisfy the needs of biomanufacturing and biotechnology companies as well as CMOs and CDMOs along the journey from drug development to commercialization.

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