A Molecular Tale of Biopolymers Narrated by SEC-MALS
Tuesday, November 19, 2024
Session 1: 10am EDT | 7am PDT | 3pm BST | 4pm CEST
Session 2: 1pm EST | 10am PDT | 6pm BST | 7pm CEST
Session 2: 1pm EST | 10am PDT | 6pm BST | 7pm CEST
Event Overview:
An inadequate characterization of drug delivery systems (including polymer therapeutics) has been defined as one of the critical factors influencing their journey from bench to bedside. To tackle these challenges, scientists need to implement fit-for-purpose analytical techniques from the start and throughout the design process.
Size and morphology of designed polymeric materials are crucial physicochemical properties that affect their biodistribution and blood circulation half-time, influencing safety and efficacy; however, the complexity of polymeric materials makes their characterization challenging. Now, there is a need for a simultaneous multidetection platform based on size exclusion chromatography to adequately address this exhaustive characterization of polymer therapeutics. The advanced detectors, with a particular emphasis on triple detection—combining refractive index, multiangle light scattering, and viscometry—offer a comprehensive approach to structural analysis, determination of molecular weight, size, and intrinsic viscosity. The integration of these detectors enhances the accuracy of polymer characterization, providing insights into molecular conformation and aggregation.
Ultimately, only by considering the principles of analytical chemistry—and performing appropriate characterization steps¬¬—can one ensure the reproducibility of their studies and in turn improve the clinical translation of polymer therapeutics.
Key Learning Objectives:
- Discover the size exclusion chromatography-multiangle light scattering (SEC-MALS) potential in unraveling the structural information of biopolymers
- Learn the critical steps in developing an accurate SEC-MALS method
- Learn the fundamentals of SEC coupled with triple-detection system
Who Should Attend:
- Polymer chemists who wish to improve their polymer characterization for bio applications and how to tackle the challenges in SEC analysis
- Scientists interested in improving their knowledge on SEC-MALS and who may be looking for new applications of this technique in biopolymer characterization
- Analytical chemists looking for an introduction of SEC-MALS and its role in biopolymer characterization
Featured Speakers:
Snežana Đorđević, PhD, MS
Application Scientist, Analytical Instruments
Tosoh Bioscience (Germany)
With a background in pharmacy and analytical chemistry, Snežana Đorđević, PhD, MS, has dedicated her career to merging her skills into polymer characterization techniques. With 6 years of experience in the rational design of polymer therapeutics, along with her expertise in many analytical techniques, she became an application scientist at Tosoh Bioscience. In this role, she is focusing on finding new applications of SEC in the characterization of polymers and polymer-based drug delivery systems.